14 research outputs found
NASA CYGNSS Mission Applications Workshop
- Publication venue
- Publication date
- Field of study
NASA's Cyclone Global Navigation Satellite System, (CYGNSS), mission is a constellation of eight microsatellites that will measure surface winds in and near the inner cores of hurricanes, including regions beneath the eyewall and intense inner rainbands that could not previously be measured from space. The CYGNSS-measured wind fields, when combined with precipitation fields (e.g., produced by the Global Precipitation Measurement [GPM] core satellite and its constellation of precipitation imagers), will provide coupled observations of moist atmospheric thermodynamics and ocean surface response, enabling new insights into hurricane inner core dynamics and energetics. The outcomes of this workshop, which are detailed in this report, comprise two primary elements: (1) A report of workshop proceedings, and; (2) Detailed Applications Traceability Matrices with requirements and operational considerations to serve broadly for development of value-added tools, applications, and products
Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease: results from the IMmunogenicity to Second Anti-TNF Therapy (IMSAT) therapeutic drug monitoring study
- Author
- Abdulgader Amin
- Ahmad Tariq
- Akhtar Muhammad
- Allahâditta Mohammed
- Alâshakhshir Sarah
- Appiahene Priscilla
- Auth Marcus K.
- Baig Daniyal
- Baker Mark
- Beale Amanda
- Beckly John
- Bell Andrew
- Bendall Oliver
- Betteridge Frederica
- Black Karen
- Bloom Stuart
- Borgâbartolo Simon P.
- Burton Julie
- Butterworth Jeff R.
- Cardozo Wendy
- Carlson Sean
- Carter Josiah O.
- Chanchlani Neil
- Chandy Rajiv
- Chee Desmond
- Claridge Andrew
- Colbert Roghan
- Coulter Archibald
- Cummings J. R. Fraser
- De Silva Aminda
- Derikx Lauranne A. A. P.
- Di Mambro Alex
- Donovan Fiona
- Durai Dharmaraj
- Fletcher Aimee
- Gardnerâthorpe Helen
- Gaya Daniel R.
- Gaynor Edward
- George Becky
- Gervais Lisa
- Goodhand James R.
- Gordon Claire
- Gulliver James
- Gupta Sanjay
- Hamilton Ben
- Hansen Richard
- Hart James W.
- Henderson Paul
- Hussenbux Arif
- Jagdish Reema
- Javed Asima
- Jere Mwansa
- Jones Kelsey D. J.
- Kane Patricia
- Kennedy Nicholas A.
- Kitchin Angus
- Knight Paul
- Lee Chai Leng
- Lees Charlie W.
- Lim Yuenâhui
- Lin Simeng
- Livingstone Robert
- Lockett Melanie
- Lok James
- London Emily
- London Ian
- Looi Shi
- Lupton Stephanie
- Lynch Lucy
- Macdonald Jonathan
- Maher Sebrene
- Mahmood Zahid
- Mansfield Lynne
- Marsh Liane
- Mcdonald Timothy J.
- Mclachlan Iain
- Moss Allison
- Murphy Aisling
- Murugesan Senthil V.
- Ng Tze
- Nice Rachel
- Parkinson Marian
- Pollok Richard C. G.
- Preston Cathryn
- Ramachandran Sankaranarayanan
- Riley Tom
- Robbins Helena
- Russell Richard K.
- Sebastian Shaji
- Seenan John Paul
- Selinger Christian P.
- Shields Stephanie
- Snook Jonathon
- Sonwalkar Sunil A.
- Sprakes Michael B.
- Stephenson Sophie
- Stone Helen
- Theaker Holly
- Thomas Amanda
- Walker Gareth J.
- Yadagiri Rekha
- Publication venue
- 'Wiley'
- Publication date
- 29/08/2022
- Field of study
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
- Author
- Abner Erin
- Adams Hieab H
- Adams Perrie M.
- Aguilar Miquel
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Victoria
- Amin Najaf
- Amouyel Philippe
- Apostolova Liana G.
- Arcaro Marina
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Imelda S.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Behrens Timothy W.
- Beiser Alexa S.
- Bellenguez CĂ©line
- Benito Yoland Aladro
- Bennett David A.
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Blacker Deborah
- Blesa Rafael
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paolo
- BossĂč Paola
- Bowen James D.
- Boxer Adam
- Braae Anne
- Braddel Amy
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A
- Brookes Keeley
- Brown Kristelle
- Brundin Rosemarie
- Bruni Amalia Cecilia
- Bullido MarĂa J.
- Burgess Jeremy D.
- Burke James R.
- Burns Jeffrey M.
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carrasquillo Minerva M.
- Carrell David
- Carroll Steven L.
- Cecchetti Roberta
- Chakrabarty Paramita
- Chapman Jade
- Chen Yuning
- Choi Seung-Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- ClarimĂłn Jordi
- Clark David G.
- Collinge John
- Combarros Onofre
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cupidi Chiara
- Cupples L Adrienne
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean-François
- De Deyn Peter P.
- De Jager Philip L
- Decarli Charles
- Deleuze Jean-François
- Denning Nicola
- Derbois CĂ©line
- Dermecourt Vincent
- Destefano Anita L.
- Diaz Carolina Ceballos
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W
- Dombroski Beth
- Doody Rachelle S.
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Dulary CĂ©cile
- Dunstan Melanie
- Dupuis Josée
- Eiriksdottir Gudny
- Emilsson Valur
- Engelborghs Sebastien
- Epelbaum Jacques
- Ertekin-Taner Nilufer
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- FairĂ©n MĂČnica DĂez
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernadez Carmen Muñoz
- Ferris Steven
- Fievet Nathalie
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Forsell Charlotte
- Forstner Andreas J.
- Fortea Juan
- Fox Nick C.
- Frank-GarcĂa Ana
- Fratiglioni Laura
- Frosch Matthew P.
- Funk Cory C.
- Galasko Douglas R.
- Galimberti Daniela
- Gallo Maura
- Garcia Florentino Sanchez
- Garcia Melissa E.
- Garzia Fabienne
- Gearing Marla
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Goate Alison M.
- Golamaully Feroze
- Golde Todd E.
- Graff Caroline
- Graff-Radford Neill R.
- Graham Robert R
- Green Robert C.
- Grenier-Boley Benjamin
- Grove Megan L.
- Growdon John H.
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- HenĂĄndez Isabel
- Herms Stefan
- Heun Reinhard
- Hill Matt
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hoffmann Per
- Hofman Albert
- Holmes Clive
- Honig Lawrence S.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Ikram M Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee-Way
- Johnston Janet
- Jones Lesley
- Jr W T Longstreth
- Jun Gyungah
- Kamboh M Ilyas
- Karydas Anna
- Katz Mindy J.
- Kauwe John Keoni
- Kaye Jeffrey A.
- Keene C Dirk
- Keller Lina
- Kilander Lena
- Kim Ronald
- Kinhult-StÀhlbom Anne
- Kloszewska Iwona
- Koivisto Anne Maria
- Kornhuber Johannes
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- Laferla Frank M.
- Lah James J.
- Lambert Jean-Charles
- Lannfelt Lars
- Larson Eric B.
- Lawlor Brian
- Leber Markus
- Leverenz James B.
- Levey Allan I.
- Levy Daniel
- Li Ge
- Li Hongdong
- Li Shuo
- Lieberman Andrew P.
- Lilius Lena
- Lin Honghuang
- Lipton Richard B.
- LleĂł Alberto
- Lopez Oscar L.
- Lord Jenny
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Maier Wolfgang
- Majounie Elisa
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mayeux Richard
- Mayhaus Manuel
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John C.
- Mosley Thomas H.
- Mukherjee Shubhabrata
- Munger Ron
- Murrell Jill R.
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C
- Naranjo Maria Candida Deniz
- Norton Maria
- Nöthen Markus M.
- O'Bryant Sid
- O'Donnell Christopher J.
- O'Donovan Michael C.
- Olaso Robert
- Olichney John M.
- Orfei Maria Donata
- Ortega-Cubero Sara
- Owen Michael J.
- Pankratz Vernon S.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pichler Sabrina
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John
- Price Nathan D.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Rotter Jerome I.
- Royall Donald R.
- Rubinsztein David C
- Ruiz Agustin
- Rujescu Dan
- Sacchinelli Eleonora
- Sager Mark A.
- Sano Mary
- Satizabal Claudia L.
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lon S.
- Seeley William W.
- Septier Gislain
- Seripa Davide
- Serpente Maria
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Sleegers Kristel
- Smith Albert V.
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Sonnen Joshua A.
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- St George-Hyslop Peter
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- SĂĄnchez-Juan Pascual
- Tanzi Rudolph E.
- Tarraga Lluis
- Taylor Sarah
- Thomas Charlene
- Thomas Rhodri
- Thonberg Hakan
- Thornton-Wells Tricia A.
- Todd Stephen
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz Joann
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Tzourio Christophe
- Tzourio Christophe
- Uitterlinden Andre G.
- Uphill James
- Urbano Maria
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- Van Der Lee Sven J
- Van Duijn Cornelia M.
- Van Eldik Linda J.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vellas Bruno
- Vinters Harry V.
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li-San
- Wang Xue
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wingo Thomas S.
- Winslow Ashley R.
- Wolters Frank J
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang-Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Publication date
- 01/01/2017
- Field of study
We identified rare coding variants associated with Alzheimerâs disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1Ă10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5Ă10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38Ă10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56Ă10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55Ă10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- AlnĂŠs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- BĂŒlow Robin
- BĂŒlow Robin
- BĂŒrger Christian
- BĂżchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde LucĂa
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo TĂąnia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
- DeMarco Kathryn
- den Braber Anouk
- Dennis Michelle F
- Depondt Chantal
- Desrivieres Sylvane
- DesriviĂšres Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
- Dohm Katharina
- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
- Dooley Eoin
- Doraiswamy P Murali
- Drost Dick
- Duara Ranjan
- Dubow Jordan S
- Dunlop Becky
- Egebjerg Jan
- Ehrlich Stefan
- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espay Alberto
- Espay Kristy
- Espeseth Thomas
- Espiritu Ryan
- Faber Kelley
- Factor Stewart
- Fan Chun Chieh
- Fargher Kristin
- Farlow Martin R
- Fatica Parianne
- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernåndez Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
- Fillmer Ariane
- Finger Elizabeth
- Fisher Simon E
- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
- Flor Herta
- Flor Herta
- Foley Sonya F
- Fontaine Deborah
- Fontoura Paulo
- Ford Judith M
- Fornage Myriam
- Fornage Myriam
- Foroud Tatiana
- Foroud Tatiana M
- Forstner Andreas J
- Foster Eric
- Foster Norm
- Fox Nick
- Francks Clyde
- Frank Richard
- Frank Samuel
- Franke Barbara
- Franklin Erin
- Franz Carol E
- Frasier Mark
- Frouin Vincent
- Fröhner Juliane
- Fukunaga Masaki
- Gaikwad Mrunalini
- Galasko Douglas
- Garavan Hugh
- Garijo Daniel
- Garrett Melanie E
- Gauss Katharina
- Ge Tian
- Geldmacher David
- Gessert Devon
- Ghanbari Mohsen
- Giddaluru Sudheer
- Gigliotti Christina
- Gil Yolanda
- Gillespie Nathan A
- Glahn David C
- Gloer Katherine
- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
- Green Robert C
- Green Robert C
- Greig-Custo Maria T
- Griffith Randall
- Grimmer Yvonne
- Groenewold Nynke A
- Grossman Hillel
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
- Hariri Ahmad R
- Harlan Sherry
- Harless Kelly
- Harris Mat
- Harris Mathew A
- Harrison Marc B
- Hart David
- Hartman Catharina A
- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
- Hauser Robert
- Hawkins Keith A
- Hefti Franz
- Heidebrink Judith L
- Heindel Walter
- Heinz Andreas
- Heinz Andreas
- Heinzen Erin L
- Henskens Frans A
- Hergesheimer Lindsey
- Herms Stefan
- Hernando Raymundo
- Herring Scott
- Heslenfeld Dirk J
- Hetelle Joel
- Hewitt David L
- Heyn Chris Chinthaka
- Hibar Derrek P
- Hillegers Manon H J
- Himali Jayandra J
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J
- Hofer Edith
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U
- Hofman Albert
- Hogarth Penelope
- Hohmann Sarah
- Holleran Laurena
- Holmes Avram J
- Holsboer Florian
- Holtzman David
- Homuth Georg
- Hong L Elliot
- Honig Lawrence S
- Hoogman Martine
- Hopkins William D
- Hosein Chris
- Hosten Norbert
- Hottenga Jouke-Jan
- Hsiao John
- Hsiung Ging-Yuek Robin
- Hu Shu-Ching
- Hulshoff Pol Hilleke E
- Hunter Christine
- Hynes Mary L
- HĂ€usler Alexander N
- HĂ„berg Asta K
- Ihlenfeld Albrecht
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Arfan
- Ing Alex
- Initiative Alzheimerâs Disease Neuroimaging
- Initiative Parkinsonâs Progression Markers
- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
- Ismail M Saleem
- Ittermann Bernd
- Jack Clifford R
- Jack Clifford R
- Jagust William
- Jahanshad Neda
- James Angela
- James Olga
- James Raymond
- Jang MiHyun
- Jankovic Joseph
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E
- Jennings Danna
- Jernigan Terry L
- Jia Tianye
- Jia Tianye
- Jian Xueqiu
- Jiang Jiyang
- Jicha Greg
- Jimenez Gustavo
- Jockwitz Christiane
- Johnson Kathleen
- Johnson Keith A
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
- Jones David
- Jönsson Erik G
- Kahn René S
- Kanai Ryota
- Kantarci Kejal
- Karama Sherif
- Karama Sherif
- Karlawish Jason H
- Kasperaviciute Dalia
- Kass Joseph S
- Kataki Maria
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- Weinberger Daniel R
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- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
A novel Alzheimer disease locus located near the gene encoding tau protein
- Author
- Adams Perrie M
- Al-Chalabi Ammar
- Albert Marilyn S
- Albin Roger L
- Alegret Montserrat
- Alpérovitch Annick
- Alvarez Victoria
- Amin N.
- Amouyel P.
- Apostolova Liana G
- Arnold Steven E
- Asthana Sanjay
- Atwood Craig S
- Au Rhoda
- Avramidou Despoina
- Baldwin Clinton T
- Barber R.
- Barberger-Gateau Pascale
- Barmada Michjael M
- Barnes Lisa L
- Bass Nicholas J
- Bayer Anthony
- Beach Thomas G
- Becker James T
- Becker James T
- Becker T.
- Beecham G. W.
- Beekly D.
- Beiser Alexa
- Bellenguez C.
- Ben-Shlomo Yoav
- Benke Thomas
- Bennett D. A.
- Berr C.
- Bettens Karolien
- Bigio Eileen H
- Bird Thomas D
- Bis J. C.
- Bisceglio Gina
- Blacker Deborah
- Boada M.
- Boerwinkle Eric
- Boeve Bradley F
- Boland A.
- BossĂč Paola
- Bowen James D
- Boxer Adam
- Brayne C.
- Bressler Jan
- Brice Alexis
- Brown Kristelle
- Bullido Maria
- Burke James R
- Bussche Hendrik van den
- Buxbaum J. D.
- Caffara Paolo
- Cairns Nigel J
- Campion D.
- Cantwell L. B.
- Cao Chuanhai
- Carasquillo M.
- Carlson Chris S
- Carlsson Cynthia M
- Carney Regina M
- Carrasquillo Minerva M
- Carroll Steven L
- Chapman Jade
- Choi S-H
- Chouraki V.
- Chui Helena C
- Chung J.
- Clarimon Jordi
- Clark David G
- Clarke R.
- Collinge John
- Combarros Onofre
- Corneveaux Jason
- Coto Eliecer
- Craig David
- Crane P. K.
- Cribbs David H
- Crocco Elizabeth A
- Cruchaga C.
- Cruchaga Carlos
- Dal-Bianco Peter
- Dartigues J-F
- de Bruijn R. F. A. G.
- De Jager P.
- De Jager Philip L
- DeCarli Charles
- DeKosky Steven T
- Delepine Marc
- Deloukas Panagiotis
- Demirci F Yesim
- Deniz Naranjo Maria Candida
- Denning N.
- Deramecourt V.
- Destefano A. L.
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W
- Dickson Dennis W
- Doody Rachelle S
- Drichel Dmitriy
- Duara Ranjan
- Dufouil C.
- Dunstan M. L.
- Eiriksdottir G.
- Emilsson V.
- Epelbaum Jacques
- Ertekin-Taner Nilufer
- Escott-Price V.
- Evans D.
- Faber Kelley M
- Fairchild Thomas J
- Fallon Kenneth B
- Farlow Martin R
- Farrer L. A.
- Ferris Steven
- Feulner Thomas
- Fievet N.
- Fisher Elizabeth
- Fitzpatrick A. L.
- Fornage Myriam
- Foroud T. M.
- Fox N. C.
- Fratiglioni Laura
- Freudenberger Paul
- Frosch Matthew P
- Frölich Lutz
- Galasko Douglas R
- Galimberti Daniela
- Gallacher John
- Garcia Florentino Sanchez
- Gearing Marla
- Germanou Antonia
- Gerrish Amy
- Geschwind Daniel H
- Ghetti Bernardino
- Gilbert John R
- Gill M.
- Gkatzima Olymbia
- Glass Jonathan D
- Goate A. M.
- GonzĂĄlez-Perez Antonio
- Graff Caroline
- Graff-Radford Neill R
- Graff-Radford Neill R
- Green Robert C
- Grenier-Boley B.
- Growdon John H
- Gu Wei
- Gudnason V.
- Guerreiro Rita
- Gurling Hugh
- Gwilliam Rhian
- Haines J. L.
- Hakonarson Hakon
- Hamilton Ronald L
- Hamilton-Nelson K. L.
- Hampel H.
- Hannequin D.
- Hanon O.
- Hardy J.
- Hardy John
- Harold D.
- Harrell Lindy E
- Harris Tamara B
- Head Elizabeth
- HernĂĄndez Isabel
- Herold Christine
- Heun Reiner
- Heuser Isabella
- Hiltunen Mikko
- Hoffmann Per
- Hofman A.
- Hollingworth Paul
- Holmans P.
- Holmes C.
- Honig Lawrence S
- Hooper Nigel M
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- Kaye Jeffrey A
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- Kim Ronald
- Klopp Norman
- Koo Edward H
- Kornhuber Johannes
- Koudstaal Peter J
- Koutroumani Maria
- Kowall Neil W
- Kramer Joel H
- Kukull W. A.
- Kuller Lewis H
- Kunkle B. W.
- Kölsch Heike
- Lacour André
- LaFerla Frank M
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- Lambert J-C
- Lannfelt Lars
- Larson E. B.
- Lathrop M.
- Launer L. J.
- Lawlor Brian
- Laza A R
- Letenneur L.
- Leverenz James B
- Levey Allan I
- Li Ge
- Lieberman Andrew P
- Lin Chiao-Feng
- Livingston Gill
- LlĂšo Alberto
- Longstreth Jr William T
- Lopez O. L.
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- Lord Jenny
- Love S.
- Lovestone Simon
- Lumley Thomas
- Lunetta K. L.
- Lupton Michelle
- Lyketsos Constantine G
- Lynch Aoibhinn
- Ma Li
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- Makrina Daniilidou
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- Mann David
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- Marson Daniel C
- Martin E. R.
- Martiniuk Frank
- Mash Deborah C
- Masliah Eliezer
- Mateo Ignacio
- MauleĂłn Ana
- Mayeux R.
- Mayhaus Manuel
- Mayo Kevin
- McCormick Wayne C
- McCurry Susan M
- McDavid Andrew N
- McGuinness Bernadette
- McKee Ann C
- McQuillin Andrew
- Mead S.
- Mecocci Patrizia
- Medway Christopher
- Mesulam Marsel
- Miller Bruce L
- Miller Carol A
- Miller Joshua W
- Moebus Susanne
- Montine T. J.
- Morgan Angharad
- Morgan K.
- Morris John C
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- Murrell Jill R
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- O'Donovan M. C.
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- Pericak-Vance M. A.
- Perry William
- Peskind Elaine
- Petersen Ronald C
- Pichler Sabrina
- Pickering-Brown Stuart
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W
- Potter Huntington
- Powell J. F.
- Proitsi Petroula
- Psaty B. M.
- Psy DClin
- Quinn Joseph F
- Raj Ashok
- Ramirez A.
- RamĂrez-Lorca Reposo
- Ransmayr Gerhard
- Raskind Murray
- Reiman E. M.
- Reisberg Barry
- Reisch Joan S
- Reitz Christiane
- Rice Kenneth
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M
- Rivadeneira Fernando
- Roberson Erik D
- Roca Maitee Rosende
- Rogaeva Ekaterina
- Rosen Howard J
- Rosenberg Roger N
- Rossor Martin
- Rotter J. I.
- Royall Donald R
- Rubinsztein David C
- Rujescu D.
- Russo Giancarlo
- Ryan Natalie
- Sager Mark A
- Sano Mary
- Satizabal Claudia
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- Scarpini Elio
- Schellenberg G. D.
- Schmidt H.
- Schmidt R.
- Schneider Julie A
- Schneider Lon S
- Schott Jonathan M
- SchĂŒrmann Britta
- Seeley William W
- Seripa Davide
- Seshadri S.
- Shaw Christopher E
- Sims R.
- Singleton Andrew B
- Sleegers Kristel
- Smith A David
- Smith A. V.
- Smith Amanda G
- Soininen Hlikka
- Sonnen Joshua A
- Sorbi Sandro
- Spalletta Gianfranco
- Spina Salvatore
- St George-Hyslop P. H.
- Stern Robert A
- Stretton Alexandra
- Tanzi Rudolph E
- Thomas Charlene
- Thornton-Wells Tricia A
- Todd Stephen
- Toeglhofer Anna M
- Trojanowski John Q
- Troncoso Juan C
- Tsolaki Magda
- Tsuang Debby W
- Turton James
- Tzourio C.
- TĂĄrraga L.
- Töglhofer Anna Maria
- Uitterlinden Andre G
- Uphill James
- Valladares O.
- Van Broeckhoven C.
- Van Deerlin Vivianna M
- van der Lee S. J.
- van Duijn C. M.
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- Vardarajan Badri N
- Vardy Emma
- Vinters Harry V
- Vonsattel Jean Paul
- Vronskaya M.
- Wallon David
- Wang L-S
- Warden Donald
- Warner Nick
- Warren Jason D
- Weintraub Sandra
- Welsh-Bohmer Kathleen A
- Wendland J. R.
- Wichmann H-Erich
- Wilcock Gordon
- Wilhelmsen K. C.
- Williams J.
- Williamson Jennifer
- Wiltfang Jens
- Winslow A. R.
- Wishnek Sarah
- Wolf Philip A
- Woltjer Randall L
- Wright Clinton B
- Wu Chuang-Kuo
- Younkin S. G.
- Yu Chang-En
- Yu Lei
- Zampo Maria del
- Zelenika D.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/03/2015
- Field of study
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordAPOE Δ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE Δ4+ (10 352 cases and 9207 controls) and APOE Δ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE Δ4 status. Suggestive associations (P<1 Ă 10-4) in stage 1 were evaluated in an independent sample (stage 2) containing 4203 subjects (APOE Δ4+: 1250 cases and 536 controls; APOE Δ4-: 718 cases and 1699 controls). Among APOE Δ4- subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between KANSL1 and LRRC37A on chromosome 17 near MAPT) in a meta-analysis of the stage 1 and stage 2 data sets (best SNP, rs2732703, P=5·8 Ă 10-9). Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100-kilobase region that includes MAPT. Except for previously identified AD loci showing stronger association in APOE Δ4+ subjects (CR1 and CLU) or APOE Δ4- subjects (MS4A6A/MS4A4A/MS4A6E), no other SNPs were significantly associated with AD in a specific APOE genotype subgroup. In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with rs1595014 in TMEM106B (P=1·6 Ă 10-7) is noteworthy, because TMEM106B variants have previously been associated with risk of frontotemporal dementia. Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four KANSL1 probes that target transcription of the first translated exon and an untranslated exon in hippocampus (Pâ€1.3 Ă 10-8), frontal cortex (Pâ€1.3 Ă 10-9) and temporal cortex (Pâ€1.2 Ă 10-11). Rs113986870 is also strongly associated with a MAPT probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2 Ă 10-6) and temporal cortex (P=2.6 Ă 10-6). Our APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region. Replication of this finding in independent samples is needed to verify that SNPs in this region have significantly stronger effects on AD risk in persons lacking APOE Δ4 compared with persons carrying this allele, and if this is found to hold, further examination of this region and studies aimed at deciphering the mechanism(s) are warranted
New insights into the genetic etiology of Alzheimerâs disease and related dementias
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- Tuomo Mantere
- Tuomo Meretoja
- Tuovila O.
- Turpeinen M.
- Turton J.
- Turunen J. A.
- Tushar Bhangale
- Tuula Salo
- Tuuli Sistonen
- TybjĂŠrg-Hansen A.
- Tzourio C.
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- Uitterlinden A.
- Ulla Palotie
- Ullgren A.
- Ulstein I.
- Ulvi Gursoy
- Uphill J.
- Urho Kujala
- Usiskin K.
- Uusitalo H.
- Uusitalo-JĂ€rvinen H.
- Vacca A.
- Vaclav Matoska
- Vainio S.
- Valentina Ciullo
- Valeria Cores
- Valero S.
- Valladares O.
- Valladares O.
- Valory Pavlik
- Valtteri Julkunen
- van Adelsberg J.
- Van Deerlin V. M.
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- van Swieten J.
- Vance J.
- Vandenberghe R.
- Vardarajan B. N.
- Vardy E.
- Vargas L.
- Vassar R.
- Veikko Salomaa
- Veli-Matti Kosma
- Venkat Subramaniam Rathinakannan
- Verhey F.
- Vesa Aaltonen
- Vicente M. P.
- Victor W Henderson
- Victoria Fernandez-Hernandez
- Victoria Perez
- Victoriana MartĂnez
- Vidal J. -S.
- Vigo-Ortega R.
- Vilas R. H.
- Vinay Mehta
- Vincent Deramecourt
- Vincent Deramerourt
- Vincent Llorens
- Vinters H. V.
- Virolainen P.
- Vivancos L.
- Vivianna M Van Deerlin
- Vogelgsang J.
- Vojinovic D.
- Vonsattel J. -P.
- Voutilainen M.
- Vuokko Anttonen
- Vyhnalek M.
- Wadhawan S.
- Wagner M.
- Wallon D.
- Wang C.
- Wang L. -S.
- Wang R.
- Wang Y.
- Warden D.
- Waring J.
- Waring J.
- Warner N.
- Warren J. D.
- Waterworth D.
- Wayne C McCormick
- Wayne W Poon
- Weber H.
- Wei Gu
- Wei Zhou
- Weinhold L.
- Weinstein G.
- Weintraub S.
- Welsh-Bohmer K. A.
- Whelan C.
- Whitehead P. L.
- Wichmann H. -E.
- Wigmore E.
- Wijsman E. M.
- Wilcock G.
- Wilhelmsen K. C.
- Will S Bush
- William Kremen
- William Nash
- William W Seeley
- Williams A.
- Williams B.
- Williams D.
- Williams J.
- Williamson J.
- Wilms H.
- Wiltfang J.
- Windle G.
- Wingo T. S.
- Wisniewski T.
- Wittfeld K.
- Woltjer R. L.
- Wong R.
- Woods B.
- Woon M.
- Wright C. B.
- Wu C. -K.
- Wu Y.
- Xia T. -H.
- Xing Chen
- Xinli Hu
- Xiongwei Zhu
- Xu E.
- Xu F.
- Xuan Liu
- Yanbing Wang
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Yasaman Saba
- Yash Patel
- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
- Zare H.
- Zdenka Pausova
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C. P.
- Zompo M. D.
- Zulaica M.
- Zulma Sevillano
- Ălvarez V.
- Ă sa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
- Author
- A Olmos-Alonso
- A Ruiz
- AC Naj
- Adam Boxer
- Adam C Naj
- Agustin Ruiz
- Aimee Pierce
- AL Richards
- Albert Hofman
- Albert V Smith
- Alberto LleĂł
- Alberto Pilotto
- Alessio Squassina
- Alexa S Beiser
- Alexis Brice
- Alfredo Ramirez
- Alison M Goate
- Allan I Levey
- Alun Meggy
- Amalia Cecilia Bruni
- Amanda B Kuzma
- Amanda G Smith
- Amanda J Myers
- Ammar Al-Chalabi
- Amy Braddel
- Amy Gerrish
- Ana Frank-GarcĂa
- Andre G Uitterlinden
- Andreas J Forstner
- Andrew J Saykin
- Andrew N McDavid
- Andrew P Lieberman
- Angela Hodges
- Anita L DeStefano
- Ann C McKee
- Anna Karydas
- Annakaisa Haapasalo
- Anne Boland
- Anne Braae
- Anne Kinhult-StÀhlbom
- Anne Maria Koivisto
- Annette L Fitzpatrick
- Annette M Hartmann
- Antonio Ciaramella
- Antonio Daniele
- Aoibhinn Lynch
- Ashley R Winslow
- Ashok Raj
- ASP Lim
- B Devlin
- B Howie
- Badri N Vardarajan
- Barry Reisberg
- Benedetta Nacmias
- Benjamin Grenier-Boley
- Bernadette McGuinness
- Bernardino Ghetti
- Beth Dombroski
- BN Vardarajan
- BN Vardarajan
- BP Fairfax
- Bradley F Boeve
- Bradley T Hyman
- Brian Lawlor
- Brian W Kunkle
- Bruce L Miller
- Bruce M Psaty
- Bruno Dubois
- Bruno Vellas
- C Cruchaga
- C Dirk Keene
- C Fuchsberger
- C Igartua
- C Schwab
- Carlo Caltagirone
- Carlo Masullo
- Carlos Cruchaga
- Carmen Muñoz Fernadez
- Carol A Miller
- Carol Brayne
- Carole Dufouil
- Carolina Ceballos Diaz
- Caroline Graff
- Chang-En Yu
- Charlene Thomas
- Charles C White
- Charles DeCarli
- Charlotte Forsell
- Chiara Cupidi
- Chiara Fenoglio
- Chris Corcoran
- Chris S Carlson
- Christiane Reitz
- Christine M Hulette
- Christine Van Broeckhoven
- Christophe Tzourio
- Christopher E Shaw
- Christopher J O'Donnell
- Christopher Medway
- Chuang-Kuo Wu
- Chuanhai Cao
- CJ Willer
- Claudia L Satizabal
- Claudine Berr
- Clinton B Wright
- Clinton T Baldwin
- Clive Holmes
- Constantine G Lyketsos
- Cornelia M van Duijn
- Cory C Funk
- Craig S Atwood
- Cynthia M Carlsson
- CĂ©cile Dulary
- CĂ©line Bellenguez
- CĂ©line Derbois
- D Harold
- D Paris
- Dan Rujescu
- Daniel C Marson
- Daniel H Geschwind
- Daniel Levy
- Daniela Galimberti
- David A Bennett
- David C Rubinsztein
- David Carrell
- David Craig
- David G Clark
- David H Cribbs
- David Mann
- David W Fardo
- David Wallon
- Davide Seripa
- Debby W Tsuang
- Deborah Blacker
- Deborah C Mash
- Delphine Bacq
- Denis A Evans
- Denise Harold
- Dennis W Dickson
- Didier Hannequin
- Dominique Campion
- Donald R Royall
- Douglas R Galasko
- Duane Beekly
- Eden R Martin
- Eileen H Bigio
- Ekaterina Rogaeva
- Elaine Peskind
- Eleonora Sacchinelli
- Eliecer Coto
- Eliezer Masliah
- Elio Scarpini
- Elisa Majounie
- Elizabeth A Crocco
- Eric B Larson
- Eric Boerwinkle
- Eric M Reiman
- Erik D Roberson
- Erin Abner
- Fabienne Garzia
- Fernando Rivadeneira
- Feroze Golamaully
- Florence Pasquier
- Florentino Sanchez Garcia
- Francesco Panza
- Frank J Wolters
- Frank Jessen
- Frank M LaFerla
- Frank Martiniuk
- G Chan
- G Jun
- Gail P Jarvik
- Gary W Beecham
- Ge Li
- Gerard D Schellenberg
- Gianfranco Spalletta
- Gislain Septier
- Gudny Eiriksdottir
- Gyungah Jun
- H Neumann
- Hakan Thonberg
- Hakon Hakonarson
- Harald Hampel
- Harry V Vinters
- Helena C Chui
- Helena Schmidt
- Henry L Paulson
- Hieab H Adams
- Hilkka Soininen
- HM Wisniewski
- Hongdong Li
- Honghuang Lin
- Howard J Rosen
- Huntington Potter
- I Surakka
- I Tachmazidou
- Imelda S Barber
- Ina Giegling
- Isabel HenĂĄndez
- Iwona Kloszewska
- J Hunkapiller
- J Wessel
- J Xing
- J-C Lambert
- J-C Lambert
- Jacques Epelbaum
- Jade Chapman
- James B Leverenz
- James D Bowen
- James J Lah
- James R Burke
- James T Becker
- James Turton
- James Uphill
- Janet Johnston
- Jayanadra J Himali
- JC Nolz
- JD Milner
- JD Ulrich
- Jean Paul Vonsattel
- Jean-Charles Lambert
- Jean-François Dartigues
- Jean-François Deleuze
- Jeffrey A Kaye
- Jeffrey M Burns
- Jennifer A Brody
- Jennifer Williamson
- Jenny Lord
- Jeremy D Burgess
- Jerome I Rotter
- JI Goldstein
- Jill R Murrell
- JK Pritchard
- Joan S Reisch
- JoAnn Tschanz
- Joel H Kramer
- Johanna Jakobsdottir
- Johannes Kornhuber
- John C Morris
- John Collinge
- John H Growdon
- John Hardy
- John Keoni Kauwe
- John M Olichney
- John M Ringman
- John Malamon
- John Morris
- John Powell
- John Q Trojanowski
- John R Gilbert
- Jonathan L Haines
- Jordi ClarimĂłn
- Jose Bras
- Joseph D Buxbaum
- Joseph E Parisi
- Joseph F Quinn
- Joseph T Hughes
- Joshua A Sonnen
- Joshua C Bis
- Joshua W Miller
- Josée Dupuis
- JR Huyghe
- Juan C Troncoso
- Juan Fortea
- Julie A Schneider
- Julie Williams
- Kara L Hamilton-Nelson
- Karen Ritchie
- Kathleen A Welsh-Bohmer
- Kathryn L Lunetta
- Keeley Brookes
- Kelley M Faber
- Kenneth B Fallon
- Kevin Morgan
- Kirk C Wilhelmsen
- Kristel Sleegers
- Kristelle Brown
- L Adrienne Cupples
- Lars Lannfelt
- Laura B Cantwell
- Laura Fratiglioni
- Lawrence S Honig
- Lee-Way Jin
- Lei Yu
- Lena Kilander
- Lena Lilius
- Lenore J Launer
- Lesley Jones
- Letizia Concari
- Li-San Wang
- Liana G Apostolova
- Liming Qu
- Lina Keller
- Linda J Van Eldik
- Lindsay A Farrer
- Lindy E Harrell
- Lisa L Barnes
- Lluis Tarraga
- Lon S Schneider
- LS Perlmutter
- M Arfan Ikram
- M Bao
- M Gatz
- M Ilyas Kamboh
- Magda Tsolaki
- Makrina Daniilidou
- Malcolm Dick
- Manuel Mayhaus
- Margaret A Pericak-Vance
- Maria Candida Deniz Naranjo
- Maria Donata Orfei
- Maria Norton
- Maria Serpente
- Maria Urbano
- Maria Vronskaya
- Mariet Allen
- Marilyn S Albert
- Marina Arcaro
- Mark A Sager
- Markus Leber
- Markus M Nöthen
- Marla Gearing
- Marsel Mesulam
- Martin Dichgans
- Martin Ingelsson
- Martin R Farlow
- Martin Scherer
- Mary Sano
- MarĂa J Bullido
- Matt Hill
- Matthew J Huentelman
- Matthew P Frosch
- Matthias Riemenschneider
- Maura Gallo
- Megan L Grove
- Melanie Dunstan
- Melissa E Garcia
- Merce Boada
- Michael C O'Donovan
- Michael Gill
- Michael J Owen
- Michelangelo Mancuso
- Michelle K Lupton
- Mikko Hiltunen
- Mindy J Katz
- Minerva M Carrasquillo
- Miquel Aguilar
- MK Wetzel-Smith
- ML Grove
- MM Painter
- Murray Raskind
- MW Logue
- Myriam Fornage
- MĂČnica DĂez FairĂ©n
- N Patterson
- Najaf Amin
- Nandini Badarinarayan
- Nathalie Fievet
- Nathan D Price
- Neil W Kowall
- Neill R Graff-Radford
- Nick C Fox
- Nicola Denning
- Nigel J Cairns
- Nilufer Ertekin-Taner
- NJ Schork
- Oliver Peters
- Olivier Hanon
- Onofre Combarros
- Oscar L Lopez
- Oscar Sotolongo-Grau
- Otto Valladares
- P Hollingworth
- P Holmans
- P Yuan
- Paola BossĂč
- Paolo Bosco
- Paolo Caffarra
- Paramita Chakrabarty
- Pascual SĂĄnchez-Juan
- Patrice Whitehead
- Patrizia Mecocci
- Pau Pastor
- Paul K Crane
- Per Hoffmann
- Perrie M Adams
- Peter A Holmans
- Peter P De Deyn
- Peter Passmore
- Peter St George-Hyslop
- Petra Proitsi
- Philip L De Jager
- Philippe Amouyel
- PL De Jager
- Qiong Yang
- R Guerreiro
- R Rademakers
- R Talluri
- Rachel Marshall
- Rachel Raybould
- Rachelle S Doody
- Rafael Blesa
- Raffaele Giovanni Maletta
- Randall L Woltjer
- Ranjan Duara
- Rebecca Sims
- Rebecca Sussams
- Regina M Carney
- Reinhard Heun
- Reinhold Schmidt
- Rhodri Thomas
- Richard B Lipton
- Richard Mayeux
- Rik Vandenberghe
- Rita Guerreiro
- Robert A Stern
- Robert C Barber
- Robert C Green
- Robert Olaso
- Robert R Graham
- Roberta Cecchetti
- Roger L Albin
- Roger N Rosenberg
- Ron Munger
- Ronald C Petersen
- Ronald Kim
- Ronald L Hamilton
- RoseMarie Brundin
- Rudolph E Tanzi
- Russell H Swerdlow
- Ryan M Huebinger
- S Das
- S Hong
- S McCarthy
- S Sekino
- S Seshadri
- S Steinberg
- Sabrina Pichler
- Salvatore Spina
- Sandra Barral
- Sandra Weintraub
- Sandro Sorbi
- Sanjay Asthana
- Sara Ortega-Cubero
- Sarah Taylor
- SC Jin
- Sebastien Engelborghs
- Seppo Helisalmi
- Seung-Hoan Choi
- Shahzad Ahmad
- Shubhabrata Mukherjee
- Shuo Li
- Sid O'Bryant
- Simon Lovestone
- Simon Mead
- Sonia Moreno-Grau
- Stefan Herms
- Stefanie Heilmann-Heimbach
- Steffi Riedel-Heller
- Stephen Todd
- Steven E Arnold
- Steven Ferris
- Steven G Younkin
- Steven L Carroll
- Sudha Seshadri
- Susan M McCurry
- Susanne Moebus
- Sven J van der Lee
- T Jonsson
- T Jonsson
- T Kurosaki
- Taniesha Morgan
- Tatiana M Foroud
- Thomas D Bird
- Thomas G Beach
- Thomas H Mosley
- Thomas J Fairchild
- Thomas J Montine
- Thomas S Wingo
- Thor Aspelund
- Timothy W Behrens
- Todd E Golde
- Tricia A Thornton-Wells
- Ubaldo Bonuccelli
- V Escott-Price
- V Escott-Price
- Valentina Escott-Price
- Valur Emilsson
- Vernon S Pankratz
- Victoria Alvarez
- Vilmantas Giedraitis
- Vilmundur Gudnason
- Vincent Chouraki
- Vincent Dermecourt
- Vincenzo Solfrizzi
- Virginia Boccardi
- Vivianna M Van Deerlin
- W Bodmer
- W T Longstreth Jr
- Walter A Kukull
- Wayne C McCormick
- Wayne W Poon
- Wei Gu
- William Perry
- William W Seeley
- Wolfgang Maier
- Xue Wang
- Xueqiu Jian
- Y Lu
- Y Wang
- Y Wang
- Y Zhang
- Yi Zhao
- Yogen Patel
- Yoland Aladro Benito
- Yuning Chen
- Publication venue
- Nat Genet
- Publication date
- 01/01/2017
- Field of study
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 Ă 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 Ă 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 Ă 10-10, odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 Ă 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 Ă 10-14, OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease
Author Correction: Genetic meta-analysis of diagnosed Alzheimerâs disease identifies new risk loci and implicates AÎČ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)
- Author
- Abner Erin
- Adams Hieab H.
- Adams Perrie M.
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Ignacio
- Alvarez Victoria
- Amin Najaf
- Amlie-Wolf Alexandre
- Amouyel Phillippe
- Apostolova Liana G.
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Avramidou Despoina
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Bass Nicholas J.
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Beiser Alexa S.
- Bellenguez CĂ©line
- Ben-Shlomo Yoav
- Benito Yolanda A.
- Bennett David
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Bisceglio Gina
- Blacker Deborah
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paola
- BossĂč Paola
- Bowen James D.
- Boxer Adam
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A.
- Brown Kristelle
- Brundin Rose Marie
- Bruni Amalia Cecilia
- Bullido Maria J.
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Butkiewicz Mariusz
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carracedo Ăngel
- Carrasquillo Minerva M.
- Cecchetti Roberta
- Chen Yuning
- Choi Seung Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- Clarimon Jordi
- Clarke Robert
- Collinge John
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cuccaro Michael L.
- Cupidi Chiara
- Cupples L. Adrienne
- Cushion Thomas D.
- Damotte Vincent
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean Francois
- De Deyn Peter P.
- De Jager Phil L.
- de Rojas Itziar
- Debette Stéphanie
- DeCarli Charles
- Del Zompo Maria
- Deleuze Jean Francois
- Deloukas Panagiotis
- Denning Nicola
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diez-Fairen Monica
- Dombroski Beth A.
- Doody Rachelle S.
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilifur
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fisher Elizabeth
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Fox Nick C.
- Fratiglioni Laura
- Frisardi Vincenza
- Frizatti Aura
- Frosch Matthew P.
- Frölich Lutz
- Galasko Douglas R.
- Galimberti Daniela
- Gallacher John
- Gallo Maura
- Garcia Melissa E.
- Garnier Jean Guillaume
- Garzia Fabienne
- Gearing Marla
- George-Hyslop Peter St
- Germanou Antonia
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Gkatzima Olymbia
- Goate Alison M.
- Graff Caroline
- Graff-Radford Neill R.
- Green Robert C.
- Grenier-Boley Benjamin
- Growdon John H.
- Grozeva Detelina
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Gwilliam Rhian
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Helisalmi Seppo
- HernĂĄndez Isabel
- Heun Reinhard
- Heuser Isabella
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hofer Edith
- Hoffmann Per
- Hollingworth Paul
- Holmans Peter A.
- Holmes Clive
- Honig Lawrence S.
- Hooper Nigel M.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- HĂŒll Michael
- Ikram M. Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee Way
- Johnston Janet A.
- Jones Lesley
- Jun Gyungah R.
- Jöckel Karl Heinz
- Kamboh M. Ilyas
- KaramujiÄ-ÄomiÄ Hata
- Karydas Anna
- Katz Mindy J.
- Kauwe John S.K.
- Kawalia Amit
- Kaye Jeffrey A.
- Keene C. Dirk
- Kehoe Patrick G.
- Keller Lina
- Kilander Lena
- Kim Ronald
- Klopp Norman
- Kloszewska Iwona
- Koivisto Anne Maria
- Kornhuber Johannes
- Koutroumani Maria
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- Kölsch Heike
- LaFerla Frank M.
- Lah James J.
- Lambert Jean Charles
- Lannfelt Lars
- Larson Eric B.
- Launer Lenore J.
- Lawlor Brian
- Leber Markus
- Leonenko Ganna
- Leverenz James B.
- Levey Allan I.
- Li Shuo
- Lieberman Andrew P.
- Lin Honghuang
- Lipton Richard B.
- Livingston Gill
- Lleo Alberto
- Longstreth W. T.
- Lopez Oscar L.
- Lord Jenny
- Love Seth
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Ma Li
- Maier Wolfgang
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Mann David
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mateo Ignacio
- Mayeux Richard
- Mayhaus Manuel
- Mayo Kevin
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- McQuillin Andrew
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Menzies Georgina E.
- Meslage Stéphane
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
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- Morgan Taniesha
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- Morris John C.
- Mosley Thomas H.
- Moutet Marie Laure
- Mukherjee Shubhabrata
- Munger Ron
- Munoz-Fernadez Carmen
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C.
- Naranjo Maria Candida Deniz
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- Olaso Robert
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- Orellana Adelina
- Orfei Maria Donata
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- OâDonovan Michael C.
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- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William R.
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pickering-Brown Stuart
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John F.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Quintela Inés
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Real Luis M.
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rodriguez-Rodriguez Eloy
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Roshchupkin Gennady
- Rossor Martin
- Rotter Jerome I.
- Royall Donald R.
- Rubinsztein David C.
- Ruiz Agustin
- Russo Giancarlo
- Ryan Natalie S.
- Saba Yasaman
- Sacchinelli Eleonora
- Sager Mark A.
- Salani Francesca
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sano Mary
- Sarnowski Chloe
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lori S.
- Schott Jonathan M.
- Seeley William W.
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Singleton Andrew B.
- Sleegers Kristel
- Slifer Susan
- Smith A. David
- Smith Albert V.
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Song Yuenjoo
- Sonnen Joshua A.
- Sorbi Sandro
- Sordon Sabrina
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- Tang Mitchell
- Tanzi Rudolph E.
- Tarraga LluĂs
- Thonberg Hakan
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz Jo Ann
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Uitterlinden A. G.Andre
- Uphill James
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Lee Sven J.
- van Duijn Cornelia M.
- Van Eldik Linda J.
- Vance Jeffery M.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vellas Bruno
- Vinters Harry V.
- Voijnovic Dina
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li San
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wichmann H. Erich
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wiltfang Jens
- Wingo Thomas S.
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang En
- Yu Lei
- Zhao Yi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/09/2019
- Field of study
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A\u3b2, tau, immunity and lipid processing
- Author
- Abner Erin
- Adams Hieab H.
- Adams Perrie M.
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Ignacio
- Alvarez Victoria
- Amin Najaf
- Amlie-Wolf Alexandre
- Amouyel Phillippe
- Apostolova Liana G.
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Avramidou Despoina
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Bass Nicholas J.
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Beiser Alexa S.
- Bellenguez Celine
- Ben-Shlomo Yoav
- Benito Yolanda A.
- Bennett David
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Bisceglio Gina
- Blacker Deborah
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paola
- Bossu Paola
- Bowen James D.
- Boxer Adam
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A.
- Brown Kristelle
- Brundin Rosemarie
- Bruni Amalia Cecilia
- Bullido Maria J.
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Butkiewicz Mariusz
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carracedo Angel
- Carrasquillo Minerva M.
- Cecchetti Roberta
- Chen Yuning
- Choi Seung-Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- Clarimon Jordi
- Clarke Robert
- Collinge John
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cuccaro Michael L.
- Cupidi Chiara
- Cupples L. Adrienne
- Cushion Thomas D.
- Damotte Vincent
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean-Francois
- De Deyn Peter Paul
- De Jager Phil L.
- de Rojas Itziar
- Debette Stphanie
- DeCarli Charles
- Del Zompo Maria
- Deleuze Jean-Francois
- Deloukas Panagiotis
- Denning Nicola
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diez-Fairen Monica
- Dombroski Beth A.
- Doody Rachelle S.
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilifur
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fisher Elizabeth
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Fox Nick C.
- Fratiglioni Laura
- Frisardi Vincenza
- Frizatti Aura
- Froelich Lutz
- Frosch Matthew P.
- Galasko Douglas R.
- Galimberti Daniela
- Gallacher John
- Gallo Maura
- Garcia Melissa E.
- Garnier Jean-Guillaume
- Garzia Fabienne
- Gearing Marla
- Germanou Antonia
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Gkatzima Olymbia
- Goate Alison M.
- Graff Caroline
- Graff-Radford Neill R.
- Green Robert C.
- Grenier-Boley Benjamin
- Growdon John H.
- Grozeva Detelina
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Gwilliam Rhian
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Helisalmi Seppo
- Hernandez Isabel
- Heun Reinhard
- Heuser Isabella
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hofer Edith
- Hoffmann Per
- Hollingworth Paul
- Holmans Peter A.
- Holmes Clive
- Honig Lawrence S.
- Hooper Nigel M.
- Huebinger Ryan M.
- Huell Michael
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Ikram M. Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee-Way
- Joeckel Karl-Heinz
- Johnston Janet A.
- Jones Lesley
- Jun Gyungah R.
- Kamboh M. Ilyas
- Karamujic-Comic Hata
- Karydas Anna
- Katz Mindy J.
- Kauwe John S. K.
- Kawalia Amit
- Kaye Jeffrey A.
- Keene C. Dirk
- Kehoe Patrick G.
- Keller Lina
- Kilander Lena
- Kim Ronald
- Klopp Norman
- Kloszewska Iwona
- Koelsch Heike
- Koivisto Anne Maria
- Kornhuber Johannes
- Koutroumani Maria
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- LaFerla Frank M.
- Lah James J.
- Lambert Jean-Charles
- Lannfelt Lars
- Larson Eric B.
- Launer Lenore J.
- Lawlor Brian
- Leber Markus
- Leonenko Ganna
- Leverenz James B.
- Levey Allan, I
- Li Shuo
- Lieberman Andrew P.
- Lin Honghuang
- Lipton Richard B.
- Livingston Gill
- Lleo Alberto
- Longstreth W. T., Jr.
- Lopez Oscar L.
- Lord Jenny
- Love Seth
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Ma Li
- Maier Wolfgang
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Mann David
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mateo Ignacio
- Mayeux Richard
- Mayhaus Manuel
- Mayo Kevin
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- McQuillin Andrew
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Menzies Georgina E.
- Meslage Stphane
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John
- Morris John C.
- Mosley Thomas H.
- Moutet Marie-Laure
- Mukherjee Shubhabrata
- Munger Ron
- Munoz-Fernadez Carmen
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C.
- Naranjo Maria Candida Deniz
- Nicolas Gael
- Noethen Markus M.
- O'Bryant Sid
- O'Donovan Michael C.
- Olaso Robert
- Olichney John M.
- Orellana Adelina
- Orfei Maria Donata
- Owen Michael J.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William R.
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pickering-Brown Stuart
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John F.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Quintela Ines
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Real Luis M.
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rodriguez-Rodriguez Eloy
- Rogaeva Ekaterina
- Roschupkin Gena
- Rosen Howard J.
- Rosenberg Roger N.
- Rossor Martin
- Rotter Jerome, I
- Royall Donald R.
- Rubinsztein David C.
- Ruiz Agustin
- Russo Giancarlo
- Ryan Natalie S.
- Saba Yasaman
- Sacchinelli Eleonora
- Sager Mark A.
- Salani Francesca
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sano Mary
- Sarnowski Chloe
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lori S.
- Schott Jonathan M.
- Seeley William W.
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Singleton Andrew B.
- Sleegers Kristel
- Slifer Susan
- Smith A. David
- Smith Albert, V
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Song Yuenjoo
- Sonnen Joshua A.
- Sorbi Sandro
- Sordon Sabrina
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- St George-Hyslop Peter
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- Tang Mitchell
- Tanzi Rudolph E.
- Tarraga Lluis
- Thonberg Hakan
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz JoAnn
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Uitterlinden A. G. Andre
- Uphill James
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Lee Sven J.
- van Duijn Cornelia M.
- Van Eldik Linda J.
- Vance Jeffery M.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vellas Bruno
- Vinters Harry V.
- Voijnovic Dina
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li-San
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wichmann H-Erich
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wiltfang Jens
- Wingo Thomas S.
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang-Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Publication date
- 01/01/2019
- Field of study